Other studies have indicated that GH deficiency may lead to increased myostatin levels, which is an atrophic factor, with dissociation in autocrine IGF-1 effects on muscles’ protein synthesis. These are pro-sarcopenic phenomena. In adults with human immunodeficiency virus (HIV), Adrian et al. evaluated the role of tesamorelin, a GH-releasing hormone analog, in muscle mass. The results showed that among those treated patients with a clinically significant decrease in the visceral adipose tissue, tesamorelin effectively increased the density and area of the skeletal muscles, which are all anti-sarcopenic actions. Table 2 summarizes the studies performed with medications in sarcopenic patients.
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