- Retatrutide (LY3437943), a single peptide conjugated to a lipid diacid molecule, exerts a
powerful agonist effect on the human glucagon‐receptor (GCGR), GIPR, and GLP‐1R. In comparison with
the human glucagon and glucagon‐like peptide 1 (GLP‐1), retatrutide exhibits reduced potency (by a
factor of 0.3 and 0.4, respectively) on the GCGR and GLP‐1R, while displaying enhanced potency at the
human GIPR (by a factor of 8.9) when compared to the glucose‐dependent insulinotropic polypeptide
(GIP). In vitro, Retatrutide demonstrates similar efficacy to natural glucagon in evoking glucose
production within hepatocytes. While in adipocytes, it surpasses native GIP in inducing lipolysis. The
data from the trials mentioned in this manuscript indicates that Retatrutide is effective in reducing
weight in individuals with nonsyndromic obesity. Retatrutide demonstrates dosage‐dependent
pharmacokinetics, featuring a favorable half‐life of nearly 6 days, thereby enabling convenient weekly
administration. 14 Additionally, GLP‐1 and GCG are known to significantly delay GE in humans, while GIP
may have no impact on GE. Delayed GE reduces food consumption and therefore leads to weight
reduction.
Reference:
Naeem M, Imran L, Banatwala UESS. Unleashing the power of retatrutide: A possible triumph over
obesity and overweight: A correspondence. Health Sci Rep. 2024 Feb 5;7(2):e1864. doi:
10.1002/hsr2.1864. PMID: 38323122; PMCID: PMC10844714.
Retatrutide
$100.00 – $175.00
Retatrutide (LY3437943), a single peptide conjugated to a lipid diacid molecule, exerts a
powerful agonist effect on the human glucagon‐receptor (GCGR), GIPR, and GLP‐1R. In comparison with
the human glucagon and glucagon‐like peptide 1 (GLP‐1), retatrutide exhibits reduced potency (by a
factor of 0.3 and 0.4, respectively) on the GCGR and GLP‐1R, while displaying enhanced potency at the
human GIPR (by a factor of 8.9) when compared to the glucose‐dependent insulinotropic polypeptide
(GIP).
Bulk deal
| Quantity | Discount | Discounted price |
| 1 - 2 | - | - |
| 3 - 5 | 5% | - |
| 6 - 9 | 10% | - |
| 10 - 100 | 15% | - |
| Weight | .5 oz |
|---|---|
| Size | 5mg, 10mg |
4 reviews for Retatrutide
Showing 4 of 4 reviews (5 star). See all 4 reviews
Leanette (verified owner) –
Anne (verified owner) –
I am so happy that I found Advanced Research Peptides. The products work well and the cost is very reasonable! I also receive much needed bac water with each order and a lovely free case with this last order! The products are also delivered very quickly! Any questions I have, that are within legal boundaries, Danielle answers graciously!
Anonymous (verified owner) –
Fast shipping, great product
Tabitha Cable (verified owner) –
Fast shipping! Quality product!