MOTS-C 10mg

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA
region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the nucleus where
it regulates a wide range of genes in response to metabolic dysfunction. It is colocalized to mitochondria
in various tissues and is found in plasma, but the levels decline with age. Since MOTS-c has important
cellular functions as well as a possible hormonal role, it has been shown to have beneficial effects on
age-related diseases including Diabetes, Cardiovascular diseases, Osteoporosis, postmenopausal obesity
and Alzheimer. Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased
muscle homeostasis and eventual diminished physical capability, which potentially can be reversed with
MOTS-c treatment. This review examines the latest findings on biological effects of MOTS-c as a nuclear
regulatory peptide and focuses on the role of MOTS-c in aging and age-related disorders, including
mechanisms of action and therapeutic potential.
Reference:
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent
Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct
9;23(19):11991. doi: 10.3390/ijms231911991. PMID: 36233287; PMCID: PMC9570330.